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From Carrie Hill, PhD, Former About.com Guide to Alzheimer's Disease

Groundbreaking Research Shows Reversal of Alzheimer's Symptoms in Minutes

Saturday January 12, 2008
Illustration © Alzheimer's Disease Education and Referral Center, National Institute on AgingA recent report in Science Daily is brewing excitement throughout the Alzheimer's community: The Journal of Neuroinflammation published a study that showed a reversal of Alzheimer's symptoms within minutes of administering a therapeutic spinal injection.

The injection consists of etanercept, a molecule that reduces the amount of TNF (tumor necrosis factor-alpha) in the brain. TNF regulates the brain's neural impulses, but elevated levels can disrupt brain function. Higher levels of TNF have been associated with Alzheimer's disease.

Although the published study discussed just one patient, the researchers found similar results in others that received the spinal injection. Subjects ranged from having mild to severe Alzheimer's disease and showed significant, sustained improvement after receiving the treatment.

Etanercept is FDA-approved for treatment of a number of immune disorders such as rheumatoid arthritis, but it's not currently available as a treatment for Alzheimer's; it's still being investigated as a potentially safe, efficacious approach. But Dr. Sue Griffin, a prolific scientist whose research provided the basis for the current study, called the findings "unprecedented" and called for immediate follow-up studies.

This is the kind of news that stirs up many emotions for me: cautious excitement for the positive results, appreciation for science and technology, and wistfulness that my grandmother couldn't have been part of such a study. But most of all, I feel hopeful that someday there could be a world without Alzheimer's, and determination to continue doing what I do until that day arrives.

Illustration of Neurons and Neural Impulses © Alzheimer's Disease Education and Referral Center, National Institute on Aging

Comments

January 14, 2008 at 11:59 am
(1) Carol Ekstrom says:

This is marvelous and hopeful news for everyone.

January 14, 2008 at 8:51 pm
(2) meredith says:

This is fantastic news and I hope we can get our loved ones in a study very soonl

January 15, 2008 at 1:50 pm
(3) Jackie S. says:

This is a God send. Thank you Sue Griffin and all those who prepare to give the treatments in Arkansas. God speed - there are many waiting. My prayers will go up daily for a smooth transition to setting up for treatment!

January 16, 2008 at 11:52 am
(4) Robyn says:

I hope this is true. It would be a Godsend for those who have alzheimer’s.

January 16, 2008 at 12:55 pm
(5) Karen says:

I pray that this works without too many adverse side effects. By the time testing is completed, it probably will be too late to help my suffering mom; but hopefully millions of other people will benefit.

January 16, 2008 at 11:15 pm
(6) Vivian says:

GOD BLESS YOU,… and I will pray for this to be a success and I feel HOPE now as my husband is in early stages..

January 17, 2008 at 4:23 pm
(7) Norval Thurman says:

How does one enter into this study. My wife currently has alzheimer’s and has had for the passed 6 years. She is now 70 year old.

January 18, 2008 at 6:20 pm
(8) Judy Bishop says:

My sister is 65 and very advanced it would be wonderful if there was some way I could help her.

January 24, 2008 at 9:20 pm
(9) Bonnie says:

This is exciting. Mom is 81 and is in stage 7. It is a devastating disease and I pray for a break through like this for Mom and others!!

April 9, 2008 at 9:17 pm
(10) June says:

I am excited about the news; too bad my 60 year old husband won’t be able to benefit from it. He is in the late stages of Early Onset ALzheimer’s Disease ( I had him at home for eight (8) years ) but now has been placed in a Memory care unit.

April 10, 2008 at 10:15 pm
(11) Linda Glass says:

I never thought I would live to see this day! With both my parents having AZ, my Dad died after many years of hell, and now my Mom is 87 and in late stage AZ.This drug needs to be studied, and approved by the FDA SOON! We need to stop the suffering as soon as possible!

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