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Esther Heerema, MSW

New Drug Shows Significant Success in Treating Mice's Alzheimer's Symptoms

By December 19, 2011

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Several researchers have been working together and recently announced success in developing a drug that targets the symptoms of Alzheimer's disease in mice. They formed a drug called J147 that not only enhanced memory in normal mice but also prevented memory loss in mice with Alzheimer's. The research was published in the online journal PLoS ONE.

Until now, much research on drugs for Alzheimer's has focused on targeting one specific area, the amyloid beta peptide (Aß) which is the main component of the plaques affecting the brain in Alzheimer's. Noting, however, that most Alzheimer's is related to aging, J147 was designed to target several different causes of cognitive decline related to both Alzheimer's and normal aging.

Interestingly, J147's base is an Indian curry spice called Curcumin, which has been previously identified as a natural option to improve memory and even reduce pain. The researchers then added several other materials to the drug that promoted cell health.

Short term memory, long term memory, spatial memory, and working memory were all improved in normal mice who were given J147. Furthermore, when J147 was given to mice with Alzheimer's, they showed significant improvement in the ability to navigate a maze, while those who did not receive it showed no improvement.

Although it's not yet known if this will lead to success in treating humans, it's definitely another step in the right direction. I'll be watching for continued testing of J147 and pass on more information as I hear it.

On another note, check out these 6 tips to improve your memory and recall.

December 19, 2011 at 2:30 pm
(1) Ilse Schmeller says:

J147 against Alzheimer´s

How in all heavens can any scientist find out, if a mouse has ALZHEIMER´S???
Are the plaques in their brain the same as in humans?CAN that be??? There is no other possibility- and this is quite doubtable, it seems to me.

December 19, 2011 at 9:19 pm
(2) carla says:

Mice are used initialy for medical as a way to experiment with what the researchers are doing.if something shows promise as j147 does than it must be tested on humans to see if its truly valid .the science behind j147 is the most promising I’ve seen yet.it is crucial that funding is there for human trials godspeed j147! Mom,I’m keeping my promise.hang on.I will always love you.thanks carla danesi Glorias daughter,”remember Gloria,Gloria lives”

December 20, 2011 at 8:51 pm
(3) Jim says:

Another drug that targets Alzheimer’s symptoms? How many times have these researchers promised the same results. My wife of 73 years is in stage 6 and participated in a number of trial Alzheimer meds that helped considerably. We were encouraged by her improvement until the drug companies pulled the meds from the trial. Not because they didn’t work, but they didn’t work well enough to attract investors. So shame on these drug companies. It is all money driven in my opinion.

December 26, 2011 at 5:59 pm
(4) Balachandran Menon says:

I’m from India and we Indians have been using turmeric (curcumin is the active ingredient) powder in our cooking since ages. Recently we have started hearing of dementia and Alzheimer’s in India also, how come? I admit I haven’t heard of many cases in India as in the west.

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