You may have heard that taking NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen or naproxen could reduce your risk for Alzheimer's. Considering that two major studies of this theory recently reported conflicting results, I'd stick to using NSAIDs for what they were originally intended: treating pain.

The first study looked at the use of Celebrex and Aleve, but it was halted in 2004 because heart risks emerged in other studies using these drugs. Still, enough data had been collected to do some analyses, which were recently released. The data indicated that the drugs did not benefit thinking skills, nor did they prevent Alzheimer's.

The second study, published in the May 6, 2008 issue of Neurology, is the longest study of its kind and examined NSAID use and risk for Alzheimer's over a five year period. The researchers found mixed results for different kinds of NSAIDs, with ibuprofen showing the most benefit. However, other NSAIDs showed no benefit, and the researchers noted that NSAID use may not have accounted for the reduced Alzheimer's risk -- it could have been something else about the participants that influenced the results.

What does this all mean? We don't really know if NSAIDs reduce the risk for Alzheimer's and other dementias. We do know that NSAIDs, while helpful in reducing pain, also pose serious risks such as gastrointestinal bleeding. I'm inclined to only use NSAIDs if I need a pain reliever. I think other lifestyle changes, such as adopting a healthy diet and a regular exercise regimen, are safer and more effective methods of risk reduction. For more information, see How to Create Your Personal Plan for a Healthy Brain.

Photo © Gold Standard

After my previous blog citing evidence that excess belly fat can increase the risk for Alzheimer's, it's no surprise that I was drawn to a recent analysis of seven published studies looking at the link between obesity and dementia.

The analysts found that across studies, obesity increased one's risk for developing Alzheimer's or a related dementia by an average of 80%. The studies included both middle-aged and older participants from the United States, Finland, Sweden, France, and other countries.

The message here is clear: Eat a healthy diet and get moving! Even though the studies don't prove that obesity causes dementia, the link is compelling, and achieving a normal weight is beneficial in many ways.

For more information:

• Exercise and Brain Health
• Eat for Your Brain

Illustration © A.D.A.M.